Distinguishing High Cholesterol
Maggie and Her Family’s Story
“Thanks to the FH testing, the health of my entire family has vastly improved!”
About 2 years ago, I found out my cholesterol levels were too high during a body check. I did not pay much attention to it at the time as I thought this was pretty common. But after my young uncle had a sudden heart attack, I decided to take better care of myself and lower my cholesterol levels. I began exercising and changed my diet, but my cholesterol levels remained stubbornly high.
I told my doctor and he immediately suspected that I had familial hypercholesterolemia (FH) and said I should go for a FH genetic test. He explained that FH is a genetic disease and that because there are no obvious symptoms, it is often misdiagnosed as “normal high cholesterol”. This means that more than 90% of the FH patients suffer from the disease without knowing it. Like them, I never knew that FH is much more serious than normal high cholesterol and that FH sufferers like me are more likely to develop early-onset heart disease than other people.
The test results showed that one of my genes had a mutation known to cause high cholesterol. Since genes are inherited from parents, my brother also has a 50% chance of carrying that same gene mutation. I immediately urged my family to take the test. Unfortunately, both my mother and my brother have the same gene mutation, which means they also have high cholesterol.
Thanks to the FH test, our doctors can now recommend effective treatments to help me and my family reduce our cholesterol levels and lower our risk of heart disease.
This story is inspired by our users' experiences and feedbacks and is presented here as illustration. Since each patient is unique, our services should not be seen in any way as guaranteeing outcomes.
What exactly is Familial Hypercholesterolemia?
Familial Hypercholesterolemia (FH) is a genetic disorder characterized by high levels of cholesterol. If you have FH, it means that your body cannot eliminate excess low-density lipoprotein (LDL) from your bloodstream because of a mutation in one of the genes tasked with clearing cholesterol from your body. Unattended, FH can lead to early-onset heart disease. People with FH are 20 times more likely than the general population to develop early aggressive heart disease¹. Most people with FH are misdiagnosed and more than 90% do not even know they suffer from FH ² .
Who should be taking the FH Test?
Everyone with persistent high cholesterol should be taking this test, especially:
• Children with persistent LDL-C levels of ≥4.1mmol/L
• Adults with persistent LDL-C levels ≥4.9mmol/L
• Anyone with a family history of high cholesterol or premature coronary arterial diseases
How does the test help to identify FH?
Familial Hypercholesterolemia (FH) test designed to help you discover the root cause of your high cholesterol levels.
Leveraging the effectiveness of cascade screening – a proven, highly efficient testing strategy – we test 9 updated genes related to FH, namely APOB, APOE, LDLR, LDLRAP1,PCSK9, ABCG5, ABCG8, STAP1, LIPA, to identify the specific gene mutation causing your FH. The process also informs treatment options, which may include new PCSK9 inhibitors, to improve your health while reducing your risk of early heart disease.
Helping one family at a time
We’re offering special rates for your family members!
Testing positive for FH can be overwhelming for your family. Committed to foster your peace of mind, GemVCare supports you and your family by offering testing tailored to screen for your specific mutations at special rates ^.
Please click here to understand more about how it works!
^1.This test only includes the specific likely pathogenic genetic mutation of the first patient, must be confirmed and referred by a doctor, and does not include other fees (e.g. doctor consultation fee).
2. The patient must provide a copy of the first patient’s report and a doctor’s referral letter to verify the need for testing.
3. All family members receiving the test must be referred by the same clinic or hospital as the first patient.
4. The company reserves the right to make the final decision on the offer and any disputes and can change the terms and conditions of this offer without prior notice.
The FH Foundation. (n.d.). What are the risks with FH. https://thefhfoundation.org/familial-hypercholesterolemia/what-are-the-risks-with-fh#:~:text=If%20left%20untreated%2C%20people%20with,before %20the%20age%20of%2050.
Nordestgaard BG, Chapman MJ, Humphries SE, et al. Familial hypercholesterolemia is underdiagnosed and undertreated in the genera population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society. E Heart J. 2013;34(45):3478-90a.
Centers for Disease Control and Prevention. (2017, August 1). Cascade screening of familial hypercholesterolemia in the United States: public health impact and challenges.https://blogs.cdc.gov/genomics/2017/07/25/cascade_screening/