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Home > Medicate with Confidence

StatinSafe — Identify Risk of Adverse Reactions of Statins

Do you know?

Common Misconceptions about Side Effects of Cholesterol Lowering Drugs

Statins are the most commonly prescribed drugs for lowering cholesterol². However, due to the unprofessional or even wrong medical information about the side effects of cholesterol drugs circulating on the Internet, many patients with high cholesterol have misconceptions about Statins. They are worried about the side effects of Statins and do not follow doctor's medication instructions. Statins do come with side effects, but the most common side effect, muscle pain, is harmless to patients. Most importantly, drugs are used to control and avoid serious diseases. If drugs are not taken regularly and in the right amount, they will not be able to play their due role. Not only will the patient's cholesterol level remain high, but also increase the risk of developing serious diseases.

StatinSafe

Safely Medicate with Statins

STATINSAFE analyse the presence of two variants from the major genes (SLCO1B1 & ABCG2) that affect drug metabolism, helping patients analyse their risk in developing adverse reactions when taking statins. Through your genotype together with a list of related risk factors, doctors are able to identify the most precise treatment strategy for their patients to optimise treatment outcome - reduce adverse reactions and effectively lower the cholesterol level at the same time.

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Studies Showing the Prevalent use of genetic testing as a medication guideline:  

  • The number of patients willing to start statins increased by 1.5 folds³

  • Speed up the reduction of LDL-cholesterol in the first 3 months³

  • Does not reduce the effects of cardiovascular disease prevention⁴

StatinSafe helps you manage your cholesterol levels safely and effectively, reduce the risk of developing cardiovascular disease and protect your health. 

View StatinSafe flyer

Target Groups

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People with the following conditions:

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Start statins treatment
(Identify high-risk drug users) 
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Experience side effects when using statins
(Determine the need to stop or switch medication) 
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Consider resumption of statins regime
(Evaluate drug safety) 

Mr Chan’s Story 

“StatinSafe test gave me the reassurance to start the medication regime, which helped reduce my cholesterol levels effectively.”
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This story is inspired by our users' experiences and feedbacks and is presented here as illustration. Since each patient is unique, our services should not be seen in any way as guaranteeing outcomes.

I have suffered from high cholesterol for many years. Recently my cholesterol reading was off the charts so my doctor advised me to start using statins to lower the cholesterol level. Before starting the meds, I searched online and learned that certain patients taking statins can experience side effects such as muscle pain and even rhabdomyolysis in severe cases. With friends sharing similar stories, I told my doctor I was afraid to start medication.


However, my doctor insisted high cholesterol must be treated with meds; otherwise, severe cardiovascular disease, even death, would be imminent. Upon hearing my concerns, he recommended me to do StatinSafe test, a genetic test that analyses the presence of genes that increase the risk of drug-induced adverse reactions. The test results together with other risk factors would then be used as a reference to minimise the risk of adverse reactions.


In the end, my test results came back negative. With no other risk factors, I was proven not a high-risk user for statins. This makes me feel much better about following my doctor's medication advice. Since taking statins, my cholesterol level has reduced, and I have not experienced any adverse reactions. My friend also took the test and results showed that he is a high-risk user for statins, which explained his earlier adverse reactions to the drug. After his doctor prescribed an alternative medication, the side effects disappeared, and his cholesterol level also improved.


Thanks to StatinSafe, high cholesterol patients like myself can now take medication safely to manage our cholesterol levels confidently, and lower the risk of developing cardiovascular disease.

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References:

  1. Kashani, A.; Phillips, C.O.; Foody, J.M.; Wang, Y.; Mangalmurti, S.; Ko, D.T.; Krumholz, H.M. Risks associated with statin therapy: A systematic overview of randomized clinical trials. Circulation 2006, 114, 2788–2797.

  2. Top 10 Prescription Medications in the U.S. https://www.goodrx.com/drug-guide

  3. Peyser B, et al. Effects of delivering SLCO1B1 pharmacogenetic information in randomized trial and observational settings. Circ Genom Precis Med. 2018;11:e002228. doi: 10.1161/CIRCGEN.118.002228

  4. Vassy JL, Gaziano JM, Green RC, et al. Effect of Pharmacogenetic Testing for Statin Myopathy Risk vs Usual Care on Blood Cholesterol: A Randomized Clinical Trial. JAMA Netw Open. 2020 Dec 1;3(12):e2027092. doi: 10.1001/jamanetworkopen.2020.27092. PMID: 33270123; PMCID: PMC7716196.

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