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Safely Medicate With STATINSAFE Genetic Test 

Mr Chan’s Story 

“By taking the STATINSAFE test, I was able to find out having statins doesn’t pose any risk for me.
This gave me the reassurance to start the medication regime, which helped reduce my cholesterol levels effectively, and lower my risk of developing cardiovascular disease. ”
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This story is inspired by our users' experiences and feedbacks and is presented here as illustration. Since each patient is unique, our services should not be seen in any way as guaranteeing outcomes.

I have suffered from high cholesterol for many years, and my recent cholesterol reading was off the charts, so my doctor advised me to start using statins. Before starting the meds, I searched online and learned that certain patients taking statins can experience adverse reactions such as muscle pain and even rhabdomyolysis in severe cases¹. I also found out that Asians had a higher chance of experiencing adverse drug reactions. With friends and relatives sharing similar stories, I told my doctor I was afraid to start medication. 

However, my doctor insisted high cholesterol must be treated with meds; otherwise, severe cardiovascular disease, even death, would be imminent. Upon hearing my concerns, he explained the misconceptions and advised statins are generally safe. To further clear my doubts, he recommended STATINSAFE, a genetic test that analyses the presence of genes that increase the risk of drug-induced adverse reactions. The test results together with other risk factors would then be used as a reference to minimise the risk of adverse reactions.

In the end, my test results came back negative. With no other risk factors, I was proven not a high-risk user for statins; this means I have a lower risk for side effects and could safely take statins. This knowledge makes me feel much better about following my doctor's medication advice. Since taking statins, my cholesterol level has reduced, and I have not experienced any adverse reactions. 

My friend also took the test after hearing about this. His test results showed that he is a high-risk user for statins, which explained his earlier adverse reactions to the drug. After his doctor prescribed an alternative medication, the side effects disappeared, and his cholesterol level also improved.

Thanks to STATINSAFE, high cholesterol patients like myself can now take medication safely, and manage our cholesterol levels confidently.  

Common Concerns of Statin Users

Statins are the most commonly prescribed drugs for lowering cholesterol². STATINSAFE, by helping patients analyse their risk in developing adverse reactions when taking statins, enables doctors identify the right drug treatment for their patients, manage medication regime and optimise treatment outcome. 

Who should do the STATINSAFE test?  

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People starting statins treatment
(Helps identify high-risk users for drugs) 
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People experiencing side effects when using statins
(Helps determine the need to stop or switch medication) 
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People considering the resumption of a statins regime
(Helps evaluate drug safety) 

How does STATINSAFE help identify high-risk statin users?

STATINSAFE analyse the presence of two variants from the major genes - SLCO1B1 and ABCG2 - that affect drug metabolism. This information, i.e. your genotype, together with a list of related risk factors, will form the basis of a medical guideline that can help doctors determine the most precise treatment strategy and reduce adverse reactions in patients. 

Studies Showing the Prevalent use of genetic testing as a medication guideline:  

  • The number of patients willing to start statins increased by 1.5 folds³

  • Speed up the reduction of LDL-cholesterol in the first 3 months³

  • Does not reduce the effects of cardiovascular disease prevention

STATINSAFE helps you manage your cholesterol levels safely and effectively, reduce the risk of developing cardiovascular disease and protect your health. 

View STATINSAFE flyer

 

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References:
 

  1. Kashani, A.; Phillips, C.O.; Foody, J.M.; Wang, Y.; Mangalmurti, S.; Ko, D.T.; Krumholz, H.M. Risks associated with statin therapy: A systematic overview of randomized clinical trials. Circulation 2006, 114, 2788–2797.

  2. Top 10 Prescription Medications in the U.S. https://www.goodrx.com/drug-guide

  3. Peyser B, et al. Effects of delivering SLCO1B1 pharmacogenetic information in randomized trial and observational settings. Circ Genom Precis Med. 2018;11:e002228. doi: 10.1161/CIRCGEN.118.002228

  4. Vassy JL, Gaziano JM, Green RC, et al. Effect of Pharmacogenetic Testing for Statin Myopathy Risk vs Usual Care on Blood Cholesterol: A Randomized Clinical Trial. JAMA Netw Open. 2020 Dec 1;3(12):e2027092. doi: 10.1001/jamanetworkopen.2020.27092. PMID: 33270123; PMCID: PMC7716196.